It might not turn out to be quite as disastrous as it first seems. If Matic and Herrera could form a tight hardworking midfield two, and Jose could find a way to get Rashford and Martial on the pitch at the same time with Mkhi/Mata behind Lukaku then that still feels like a bloody good side. I expect our defence to improve, and Matic and Herrera should be good defensively, then I'd back our forwards to our score most teams.
Of course, all of that ignores the presence of Fellaini and I see that as being the big issue. I'd prefer to see him used as an impact player but I fear that Jose will play him from the start and most of what I've written above will be moot.