QB
Get Trey Lance at all costs. Also target QBs with great upside this season: Lawrence, Fields, Tua. If you don't get elite QBs early, I'd suggest getting at least a RB/WR combo first or RB/RB combo before drafting two QBs. From the top tier, I like Allen, Lamar, Murray and Hurts. DO NOT draft Burrow, also don't like Mahomes and Brady (you want rushing QBs). Dak Prescott and Wilson are fine.
RB
CMC > Taylor for me
I don't like Henry, Harris or Mixon as your RB1. Do like Cook and Swift, kinda like Ekeler.
Alvin Kamara and especially Barkley are amazing values if they fall a bit (I assume somewhere 3-4th round in superflex). So are Aaron Jones and James Conner but I'd rate them a tier below Kamara and Barkley. I usually stay away from Fournette and Chubb unless they drastically fall down the board.
Don't draft Zeke or Montgomery. Elijah Mitchell if he falls a bit could be nice (but SF is an unpredictable offense), and I don't like Dobbins either (Lamar runs way too much himself)
Breece Hall and Travis Etienne are the cut-off of what I'd like my starting RBs to be. So ideally you combine one of the backs mentioned above with them as your RB2 as starting RBs.
Avoid Damien Harris, Miles Sanders
Chase Edmonds could be a nice value with big upside, Clyde Edwards-Helaire as well. I reaaaaaally like Pollard as a later-round RB, and going even further down, I like Gainwell, Herbert and Singletary. But those are high upside shots which will be hit and miss, avoid having to start them on a weakly basis of course.
WR
First tier is clear: Justin Jefferson, Ja'Marr Chase, Cooper Kupp. I'd draft Jefferson and Chase over all running backs bar CMC, Taylor, Cook
Receivers I would be comfortable with as my WR1: Diggs, Lamb, AJ Brown, Tee Higgins, Michael Pittman Jr.
Receivers in early rounds I generally don't draft: Adams, Deebo, Evans, Hill, DJ Moore, Diontae Johnson
Middle rounds: I like Sutton, Jeudy, Bateman, Robinson, Michael Thomas and Waddle (a little less though).
Breakout candidates after that which I usually target: Gabe Davis, JuJu, Aiyuk, London, Toney, sometimes Skyy Moore. Also always target Julio Jones and Jahan Dotson in the last few rounds if they are still available, great upside.
TE
If he falls far enough, Kelce is nice. I usually stay away from Andrews, he's way too expensive. Waller and Kittle are fine where they are going, so is Pitts. If you don't get any of those, wait long enough on TE and draft someone like Zach Ertz, or even deeper the likes of Albert O, Cole Kmet, Pat Freiermuth. Stay away from Goedert, Hockenson, Schultz, Knox ... is usually what I do. Middle round TEs rarely break out.
Hopefully I’m not too knackered, really wanna go 7pm-2am for the first one.
