As long as the team gels by the playoffs and get there healthy, they'll be tough to beat. I would expect Nash and Kobe to be the leader of the team, Kobe is at that stage of his career where he knows he can't do it all and expect to be the hero every game in the regular season and the playoffs.
He's shown it last season where he was willing to be second fiddle to Bynum if it meant winning, as long as Nash and Howards gains his trust quickly, Kobe will play in a team.
And just how lucky is Mike Brown? He messes up the Cleveland project with arguably the most wanted player of the 2000s and his reward for that is getting to coach the Lakers?!
Edit: On hind-sight, killing the CP3 deal was probably the best thing Stern could have done for the Lakers, it left them with 4 superstars now instead of possibly just 3.