They need Kompany and Yaya to be as good as they were 2 years ago. And even then, the likes of Barca and Bayern should be able to beat them.De Bruyne alone won't, but De Bruyne, Sterling, Otamendi along side an already quality squad will be ready for an assault on the CL.
But I would say, that this is the first time they have a chance to win it. Probably the fifth biggest favorite after Barca, Bayern and two Madrid clubs.