Subjective opinion, of course, but not for me.
Based on last season, however good Matic is at the shielding role, he does have two obvious disadvantages. One, he's quite a risk averse passer. And two, he's not fast enough and agile enough to play a box-to-box role. If you ask him to push up and press, he's gonna get gassed quite early in the game.
I think in games at Old Trafford against inferior opposition, when we know we'll dominate the possession, a midfield of Fred-Pereira-Pogba whould be very agile and quick to transition defence into offence. I would prefer that to be honest.