The only people who deserve to start are DDG, Carrick, Blind, Rashford, Martial & Mata so placing them in their best positions and building the team round it...
DDG
xxxx xxxx Blind xxxx
Carrick
xxxx xxxx
Mata
Rashford Martial
In CB, if Bailly is out I would prefer Smalling, if not then Rojo.
LB, Luke Shaw has looked off the pace but there is only one way we can get him back up so I'd select him.
RB, Darmian has better of late, not good enough but better so I'd stick with him.
2xCM, This is where it gets hard if Pogba and Herrera are out, I'd play Fellaini and Schneiderlin for the fact that other than BFS (who hasn't played a competitive game in too long), they are the only midfielders in our senior squad and football as a whole seems reluctant to field young CM's, so on that basis, I'd like to see this team:
DDG
Darmian Smalling Blind Shaw
Carrick
Fellaini Schneiderlin
Mata
Rashford Martial
EDIT: That's the best formation to suit the players available, I don't like the idea of shoehorning people into a 4-2-3-1 with no good wingers, we have work rate and defensive shifts in midfield, a creator in Carrick and Mata and finishers in Rashford and Martial..