I'm not sure how we'll line up for this one. Leicester are a greater attacking threat than the two sides we have faced so far. We might retain the same line up or we could switch to a 433 to dominate the midfield. If Jose feels he needs to make some changes to deal with Leicester, I can see him choosing this line up
De Gea
Valencia Bailly Jones Darmian
Matic
Herrera--Pogba
Mkhi Lukaku Rashford
Darmian comes in because he is a better defender. Mahrez one-on-one vs Blind is not something I'm looking forward to seeing. Herrera comes in for Mata to make us defensively more solid and play 3 vs 2 in midfield.
As far as score prediction, I don't expect a clean sheet this game. So, going for a 3-1 win.