Andrew Strauss, Michael Vaughan and Kevin Pietersen all failed for the second day running as England's batting struggles in Pakistan continued.
After England's bowlers had shown encouraging form to dismiss the Patron's XI for 211 in Rawalpindi, the tourists' top order again suffered.
Mohammad Irshad, an unheralded 22-year-old seamer, took 3-22.
And England were rocking on a miserable 39-6 at stumps, with an overall lead of 84 and one day remaining.
It had been an encouraging day for England's bowlers for the most part, as James Anderson, Liam Plunkett and Shaun Udal all took three wickets.
But the home side, replying to England's 256-9 declared, staged a useful recovery from 150-9 to be all out for 211 - and that final wicket partnership might yet prove vital as the hosts target victory on Wednesday.
It was the first day's work for England's bowlers on their tour of Pakistan and they were backed up well by keeper Geraint Jones, who took five catches.
But there was a glimmer of disappointment that Matthew Hoggard was unable to take a wicket in 12 overs.
England's decision to declare on their overnight score left opener Marcus Trescothick with an unbeaten 124 to his name.
Anderson, who struggled to find his rhythm initially, was given a lift when Ashar Zaidi (11) chipped a catch to skipper Michael Vaughan at mid-on. He then found some late swing to account for Bazid Khan.
Next, Misbah-ul-Haq edged Plunkett behind and a similar shot brought about the downfall of Test opener Yasir Hameed (28) as Anderson claimed his third success.
Plunkett atoned for dropping Faisal at deep square leg off Durham team-mate Paul Collingwood by having him caught behind for nine.
Collingwood was not to be denied, however, and trapped Asim Kamal lbw for 14 to leave the home side tottering on 79-6.
The only blot on England's morning was spinner Ashley Giles' return to the team hotel with a stomach upset and he was unable to bowl.
But back-up slow bowler Udal took the opportunity to show what he can do in figures of 3-26 which included the wicket of the Patron XI's top scorer, Shehzad Malik (37).
Numbers 10 and 11 Zulqarnain Haider and Tahir Khan then both passed 30, however, before Tahir was caught behind off Plunkett.
England's second innings was a calamitous affair as six wickets fell in 13 overs.
Vaughan, batting at four, was trapped lbw for the second time in as many days, this time for a five-ball duck.
By then Strauss had been removed by left-armer Najaf Shah - caught at slip - and all-rounder Alex Loudon lasted just seven balls before inside-edging an Irshad lifter to the wicket-keeper.
The final disaster of the day was triggered by Yasir Arafat, who took 4-45 on Monday.
He added two more wickets with the scalps of Pietersen (10) and Jones (0), the latter losing middle stump as he attempted an expansive drive.
Before those late strikes, Matt Prior, who hit 50 on Monday, was the fourth man out when picking out deep square-leg with a pull shot.
His 16 is thus far the best score in England's miserable second innings.
England: M Vaughan (capt), A Strauss, M Trescothick, I Bell, K Pietersen, G Jones (wkt), A Giles, A Loudon, S Udal, L Plunkett, M Hoggard, P Collingwood, M Prior (wkt), J Anderson.
Pakistan Cricket Board Patron's XI: Asher Zaidi, Yasir Hameed, Bazid Khan, Misbah-ul-Haq, Asim Kamal, Faisal Iqbal, Imran Tahir, Yasir Arafat, Zulqarnain, Mohammad Irshad, Arshad Khan, Mohammad Asif, Najaf Shah, Shehzad Malik.
After England's bowlers had shown encouraging form to dismiss the Patron's XI for 211 in Rawalpindi, the tourists' top order again suffered.
Mohammad Irshad, an unheralded 22-year-old seamer, took 3-22.
And England were rocking on a miserable 39-6 at stumps, with an overall lead of 84 and one day remaining.
It had been an encouraging day for England's bowlers for the most part, as James Anderson, Liam Plunkett and Shaun Udal all took three wickets.
But the home side, replying to England's 256-9 declared, staged a useful recovery from 150-9 to be all out for 211 - and that final wicket partnership might yet prove vital as the hosts target victory on Wednesday.
It was the first day's work for England's bowlers on their tour of Pakistan and they were backed up well by keeper Geraint Jones, who took five catches.
But there was a glimmer of disappointment that Matthew Hoggard was unable to take a wicket in 12 overs.
England's decision to declare on their overnight score left opener Marcus Trescothick with an unbeaten 124 to his name.
Anderson, who struggled to find his rhythm initially, was given a lift when Ashar Zaidi (11) chipped a catch to skipper Michael Vaughan at mid-on. He then found some late swing to account for Bazid Khan.
Next, Misbah-ul-Haq edged Plunkett behind and a similar shot brought about the downfall of Test opener Yasir Hameed (28) as Anderson claimed his third success.
Plunkett atoned for dropping Faisal at deep square leg off Durham team-mate Paul Collingwood by having him caught behind for nine.
Collingwood was not to be denied, however, and trapped Asim Kamal lbw for 14 to leave the home side tottering on 79-6.
The only blot on England's morning was spinner Ashley Giles' return to the team hotel with a stomach upset and he was unable to bowl.
But back-up slow bowler Udal took the opportunity to show what he can do in figures of 3-26 which included the wicket of the Patron XI's top scorer, Shehzad Malik (37).
Numbers 10 and 11 Zulqarnain Haider and Tahir Khan then both passed 30, however, before Tahir was caught behind off Plunkett.
England's second innings was a calamitous affair as six wickets fell in 13 overs.
Vaughan, batting at four, was trapped lbw for the second time in as many days, this time for a five-ball duck.
By then Strauss had been removed by left-armer Najaf Shah - caught at slip - and all-rounder Alex Loudon lasted just seven balls before inside-edging an Irshad lifter to the wicket-keeper.
The final disaster of the day was triggered by Yasir Arafat, who took 4-45 on Monday.
He added two more wickets with the scalps of Pietersen (10) and Jones (0), the latter losing middle stump as he attempted an expansive drive.
Before those late strikes, Matt Prior, who hit 50 on Monday, was the fourth man out when picking out deep square-leg with a pull shot.
His 16 is thus far the best score in England's miserable second innings.
England: M Vaughan (capt), A Strauss, M Trescothick, I Bell, K Pietersen, G Jones (wkt), A Giles, A Loudon, S Udal, L Plunkett, M Hoggard, P Collingwood, M Prior (wkt), J Anderson.
Pakistan Cricket Board Patron's XI: Asher Zaidi, Yasir Hameed, Bazid Khan, Misbah-ul-Haq, Asim Kamal, Faisal Iqbal, Imran Tahir, Yasir Arafat, Zulqarnain, Mohammad Irshad, Arshad Khan, Mohammad Asif, Najaf Shah, Shehzad Malik.
