Not sure my line of work is all that comparable to a professional athlete where his body is essentially his most important asset.
Doesn’t really matter much. Long hours on a flight to a different continent, the difference in time zones, takes a toll on your body, Gary Neville is right about that, which is why it’s frustrating for clubs when players return back late from international duty and they’ve been away to south america/Asia. So yes, it is vastly different to do it for shits and giggles and when you’re essentially forced to do it