A 15-20 yard change in positioning makes a huge amount of difference when it comes to the way we progress the ball or create chances. Bruno at #10 used to try find space between the lines and leave the progression to our CMs. He will no longer do that, he'll be one of the CMs responsible for progressing the ball, defending, tracking runners and all that a CM role entails. In terms of chance creation, Ole-ball was to give Bruno a free rein and to let him do whatever he wants to do - create overloads, try risky passes, get into the box etc. With Bruno deeper, the forwards, fullbacks have to take on a lot more responsibility for chance creation.
Of course it won't magically fix all the issues but getting the balance in the team selection right is a very important one that you're understating. If you take it to the logical extreme, you would never play a team of 10 Ronaldos as talented as they may be. All the philosophy, off the ball running, intensity won't help that side. It's an extension of that from there.
The game we lost against Wolves was a 4-2-2-2 with Greenwood, Sancho, Cavani, Ronaldo as the front four. That can never happen in a 4-3-3 world.