I don't see a rout, but a comfortable 3-1 victory seems likely. A surprise return by Rooney and/or Nani opens the door for a Maximus v Commodus sarnage scene, but my guess is that Fergie will hold both back, even if they're chomping at the bit to play.
It really depends on the situation if we only lead by one but are looking quite good, he won't bring any of them on. If we are behind or it's level he will at some point. Same if we're leading comfortably, for fitness reasons.